Cannabidiol (CBD) oil is one of the hot new product in states which have legalized medical marijuana. The non-intoxicating marijuana extract is being credited with helping treat numerous medical problems — everything from epileptic seizures to anxiety to inflammation to sleeplessness. But experts say the evidence is scant for many of these touted benefits.

Worse, CBD is being produced without the regulation, causing items that vary widely in quality, said Marcel Bonn-Miller, an adjunct assistant professor of psychology in psychiatry in the University of Pennsylvania School of Medicine. “It is actually the Wild West,” Bonn-Miller said. “Joe Bob who starts up a CBD company could say regardless of the hell he wants over a label then sell it to people.”

Cannabidiol is taken from the flowers and buds of marijuana or hemp plants. It will not produce intoxication; marijuana’s “high” is brought on by the chemical tetrahydrocannabinol (THC). CBD oil is legal in 30 states where medicinal and/or recreational marijuana is legal, according to Governing magazine.

Seventeen additional states have CBD-specific laws on the books, according to Prevention magazine. Those are Alabama, Georgia, Indiana, Iowa, Kentucky, Mississippi, Missouri, N . C ., Oklahoma, South Carolina, South Dakota, Tennessee, Texas, Utah, Virginia, Wisconsin and Wyoming.

Strong Evidence for Treating Epilepsy – Just one single purported use for buy cannabidiol cbd oil, to take care of epilepsy, has significant scientific evidence supporting it. Last month, a U.S. Food and Drug Administration advisory panel unanimously recommended approval of the CBD medication Epidiolex to treat two rare types of childhood epilepsy. “That’s actually the only area where the evidence has risen to the stage in which the FDA has said this can be acceptable to approve a new drug,” said Timothy Welty, chair of the department of clinical sciences at Drake University’s College of Pharmacy and Health Sciences, in Des Moines, Iowa.

For the rest of CBD’s potential uses, there is simply not enough evidence to create a firm conclusion. For instance, some human numerous studies suggest that CBD could be good at treating symptoms of anxiety, particularly social anxiety, Bonn-Miller said. Here is the potential use for CBD with the most evidence after usefulness in epilepsy, but “there’s a reliable gap between those two,” he said. “There were numerous studies in adults, but a lot smaller compared to the epilepsy studies that were completed in kids,” Bonn-Miller said. CBD’s usefulness as being an anti-inflammatory medicine is another most promising, but those results come mostly from animal studies, experts said.

The Majority Of Uses Largely Unproven – All of those other potential uses — as being an antipsychotic, antidepressant or sleep aid “have all been studied in animals, with only 1 or 2 samples of studies in humans,” Bonn-Miller said. And Welty said the studies that have featured humans for these particular other CBD uses have either been case reports or studies that did not compare results against a control group that did not use the oil. “There’s no control, so it’s basically how can you tell if we’re coping with the true effect from the drug or simply just a placebo effect because somebody thinks they’ve been given a drug which will be beneficial?” Welty said. There are also concerns about both the quality of CBD oil being produced as well as its potential unwanted effects, the specialists added.

Insufficient Regulation Also Concerning – As a result of legally murky nature of marijuana, the FDA has not yet stepped in to regulate items like CBD oil, Bonn-Miller said. States are struggling to put regulations in place, but they don’t hold the deep pockets of the federal government. Meanwhile, a 2017 study led by Bonn-Miller found that nearly 7 of 10 CBD products didn’t contain the volume of marijuana extract promised on the label. Nearly 43 percent in the products contained not enough CBD, while about 26 percent cptgdg too much, Bonn-Miller said.

“CBD is type of a tricky drug because it’s not very well absorbed orally,” Welty explained. “Lower than 20 % of the drug is absorbed orally. If it isn’t made in the right way, you might not be getting much drug in your systemic circulation.” Worse, about 1 in 5 CBD products contained the intoxicating pot chemical THC, Bonn-Miller and his awesome colleagues found.

“That’s an issue because THC can increase anxiety. It could can even make seizures worse. These are the types of things you should be careful about,” Bonn-Miller said. “If I were a consumer, purchasing it for myself or my kid, I would want to test it to ensure that I knew what it really actually had within it, because I couldn’t trust that which was on the label,” Bonn-Miller concluded.

Potential Interactions Along With Other Meds – Studies on CBD also provide raised concerns about possible interactions with other drugs. For instance, epilepsy studies learned that “there was very clearly increases within the blood amounts of various other anti-epileptic drugs whenever people were on CBD,” Welty said.

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