A frozen embryo transfer (FET) is the move of an embryo which was previously iced, and subsequently thawed, to the uterus. Traditionally, IVF has involved ovarian stimulation then egg retrieval and fertilization of harvested eggs, followed by a fresh embryo transfer (ET) of an embryo into the womb within five days of the egg retrieval procedure, also referred to as IVF-ET. With the development of sophisticated embryo freezing and thawing methods attaining very high embryo survival rates, conventional IVF-ET (utilizing fresh embryos) has become less frequent, giving way to the more generally practiced FET.
Iced embryo move (FET) cycles have become important elements of the IVF procedure and therefore has to be performed with great care to accomplish a successful outcome. Several elements make up an excellent FET period. A proper evaluation of the uterine cavity to eliminate the existence of an intracavitary lesion (such as a polyp or fibroid that may interfere with implantation) should be carried out prior to the FET period. The vast majority of FET periods are medicated FET periods, in which oestrogen supplementation is first given in order to build up the uterine lining (known as the endometrial echo complex below ultrasound assessment), until an optimal thickness of the coating is achieved. This phase in the Eliran Mor is essential and the sort of and method of estrogen supplementation utilized (oral oestrogen pills, vaginal oestrogen suppositories, injectable oestrogen, subcutaneous oestrogen), the dosage of estrogen, and the amount of time of estrogen supplements are essential and should be personalized and adjusted to each patient based upon several factors, so that a receptive uterine lining is achieved. The second phase of the medicated FET cycle involves progesterone supplements, brought to support the coating, once an optimal uterine lining has been achieved. In medicated FET periods, progesterone is introduced as the oestrogen supplementation is adjusted and continued. Like the case of oestrogen supplements, the type, dose, and route of progesterone supplementation, is crucial. Generally, progesterone is launched as intramuscular every day injections five days ahead of the embryo move of a iced-thawed embryo. Progesterone can additionally be given as vaginal suppositories or a mixture of intramuscular shots and vaginal suppositories. The frozen embryo transfer must timed accurately towards the initiation of progesterone supplementation in order for that FET to be successful. Estrogen and progesterone supplementation is generally ongoing following the embryo transfer and thru 10 weeks of pregnancy.
An unmedicated FET period, also referred to as an organic period FET, is normally performed without any oestrogen or progesterone supplements. Rather, the oestrogen made by a normally growing ovarian follicle, then progesterone created right after spontaneous ovulation of the follicle; keep the implantation of a iced-thawed embryo, if the FET is timed properly to the duration of ovulation. All-natural cycle FETs do not allow for flexibility in the timing in the FET and are only right for individuals with normal menstruation periods, where ovulation is not hard to monitor and it is predictable.
In certain medical situations, a stimulated FET period is carried out. Inside a stimulated FET cycle the patient administers gonadotropin hormone shots (or oral ovulation induction medicines) to induce the expansion of the follicle or hair follicles. The growth of hair follicles leads towards the endogenous creation of oestrogen which in turn leads to the thickening from the uterine lining. Once follicles achieve a mature size, these are brought on to ovulate, leading to the production of endogenous progesterone, which then sets the phase for your embryo transfer of any iced-thawed embryo. Stimulated FET periods may be applied in individuals that do not ovulate naturally or in cases where conventional medicated FET cycles have been unsuccessful.
Frozen embryo transfer periods enable excellent versatility in optimization of the uterine lining before thawing of embryos, so that embryos are not thawed until the uterine lining is receptive. The fundamental contributor necessary to accomplish an properly nrrbzz and receptive uterine coating, is estrogen. In cases of an insufficient uterine coating throughout an FET cycle, as well as variants in the type of estrogen medicine, dosage, and route of management, a number of other health supplements can be added in to enhance the lining density (such as baby aspirin, pentoxifylline, vitamin e antioxidant, Viagra, G-CSF…).